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The mechanism likely involves rapid changes in retinal blood flow, increased vascular permeability, and alterations in growth factor expression as glucose levels normalize

They should add a second agent, and current recommendations prioritise an SGLT2 inhibitor or a GLP-1 receptor agonist over older drug classes [1]

In addition, treatment of a DPP-4 inhibitor in diabetic mice increased the levels of anti-inflammatory cytokines, and increased the activation of regulatory T cells, indicating an involvement in the pathology of diabetes (Tian et al., 2010)

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