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The Twelve Peptides Now Coming Off the Category 2 Restricted List Below is a clinical overview of the twelve peptides addressed by the April 2026 FDA action , organized by what patients typically ask them to do

Supports daily nutrient intake when food intake is reduced Helps maintain consistency with smaller meals and changing appetite patterns Designed to fit easily into a structured daily routine Provides simple foundational nutrition support without overcomplicating supplementation Protein Support: For Muscle Maintenance and Daily Energy Protein is one of the most important nutrition priorities while using GLP-1 medications

In February 2026, full results from the REDEFINE 2 study showed CagriSema achieving 23% weight loss at 84 weeks but falling short of its primary endpoint under the treatment policy estimand (which measures efficacy across all patients regardless of whether they completed treatment, rather than only those who remained on it)

One strategy involves engineering immunocytokines that target the inhibitory receptor TREM2 and locally release IL-2, simultaneously blocking suppression and activating T/NK cells