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The paradigm shift that began with EMPA-REG OUTCOME and LEADER has led to SGLT2 inhibitors and GLP-1 RA being recognised not only in international diabetes guidelines, but also as an important consideration for patients with T2D in CVD prevention [28,29,30, 76, 77], HF [133,134,135] and CKD [41, 102] guidelines, where it has been suggested that these agents should be considered early in the course of diabetes management
Evidence for a direct link between PAD4-mediated citrullination and the oxidative burst in human neutrophils
In the present study, utilising the above-described novel, highly translatable two-session operant food intake paradigm, rhesus macaques were administered GLP-1R agonist Ex to elucidate how GLP-1R agonism differentially modulates homoeostatic feeding regulation, hedonic valuation and palatability-driven anticipation and decision making across the two daily feeding sessions
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