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Contraindicated in patients with a history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia Syndromes (MEN 2) Not suitable for individuals with type 1 diabetes or diabetic ketoacidosis Should not be used alongside other GLP-1 receptor medications Gastric emptying may be delayed, requiring caution for procedures involving sedation or general anesthesia due to aspiration risk Use caution in those with a history of diabetic retinopathy 1-3 Consult your healthcare provider if you have a history of pancreatitis, as the medication may increase risk Serious side effects may involve hypoglycemia, kidney issues, or allergic reactions Avoid use during pregnancy and breastfeeding 1 Enhances glucose-dependent insulin secretion Suppresses glucagon secretion Slows gastric emptying Influences brain regions involved in appetite regulation, leading to reduced hunger and caloric intake Improves insulin sensitivity 1-3 Supports weight loss Helps to minimize internal inflammation and improves cardiometabolic health measures 5 Q: How long does it take to see results

Administration Codes: CPT 96372 - Therapeutic/prophylactic/diagnostic injection, subcutaneous or intramuscular (in-office administration) Modifier 59/XS - For additional separate injections on same date Modifier 25 - On E/M code when separate E/M service performed same day as injection Drug Codes (HCPCS): J3490 - Unclassified drugs (primary code for tirzepatide in physician office) C9399 - Unclassified drugs or biologicals (hospital outpatient setting) J3590 - Unclassified biologics (alternative, less commonly used) J3420 - Injection, vitamin B-12 cyanocobalamin, up to 1000 mcg (when B12 billed separately) Diabetes Diagnosis Codes (Mounjaro): E11.65 - Type 2 diabetes with hyperglycemia (strongest for medical necessity) E11.9 - Type 2 diabetes without complications E11.21 - Type 2 diabetes with diabetic nephropathy E11.40 - Type 2 diabetes with diabetic neuropathy Z79.85 - Long-term (current) use of injectable non-insulin antidiabetic drugs Obesity Diagnosis Codes (Zepbound): E66.01 - Morbid (severe) obesity due to excess calories E66.09 - Other obesity due to excess calories E66.3 - Overweight Z68.30-Z68.45 - BMI codes (required supplemental codes) Common Comorbidity Codes: I10 - Essential hypertension E78.5 - Hyperlipidemia, unspecified G47.33 - Obstructive sleep apnea K76.0 - Fatty liver, not elsewhere classified (NAFLD) M19.90 - Unspecified osteoarthritis E/M Codes: 99203-99205 - New patient office visits 99213-99215 - Established patient office visits G0447 - Face-to-face behavioral counseling for obesity, 15 min (Medicare) Counseling and Therapy Codes: 99401-99404 - Preventive medicine counseling 97802 - Medical nutrition therapy, initial assessment 97803 - Medical nutrition therapy, reassessment This reference table covers the vast majority of coding scenarios for tirzepatide

A case of vitamin B 12 deficiency with neurological complications has been reported after gastroplasty [57]