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According to the World Obesity Federations 2025 Atlas, the global number of adults living with obesity is projected to reach 1.13 billion by 2030, a 115% increase from 2010 levels

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Tirzepatide (Mounjaro) is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist licensed in the UK for type 2 diabetes and chronic weight management

Future research should focus on elucidating the precise molecular pathways involved in oxidative stress and exploring novel antioxidant therapies that could restore balance to the redox environment within the testes, ultimately enhancing fertility outcomes in affected individuals ( 2.3 Destruction of the blood-testis barrier and induction of autoimmune responses The blood-testis barrier (BTB) serves as a critical protective structure that maintains the immunological privilege of the testicular environment, allowing for the development of germ cells without interference from the immune system ( Moreover, the breakdown of the BTB is not merely a localized phenomenon