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Symptoms of anaphylaxis include: tingling in the palms of the hand, soles of the feet, and lips swollen tongue, throat, mouth, and face difficulty breathing rapid but weak pulse Anyone who suspects anaphylaxis should call 911 and seek emergency medical care

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EGF is bioactive but barrier-limited: the molecule does what it does only if it reaches the keratinocyte layer, and standard topical formulations deposit most of it on the stratum corneum where it has no relevant receptor