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In INS-1 cells, xGLP-E4 induced a higher level of insulin secretion than human GLP-1 in the presence of a high (16.7 mM) concentration of glucose (Fig

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Clinically defined by excessive hepatic lipid accumulation in the absence of excessive alcohol intake or other secondary causes of liver injury, NAFLD exhibits a strong bidirectional association with metabolic syndrome: up to 75% of adults with cardiometabolic conditions (e.g., obesity, T2DM, dyslipidemia) develop NAFLD, while NAFLD itself exacerbates systemic metabolic dysfunction (Steinberg et al., 2025)

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