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In addition, excessive alcohol intake enhances hepatic protein levels of SREBP1c, a transcription factor that elevates the expression of genes involved in lipid synthesis (Hu et al., 2022)

GPx-1 is particularly important in the antioxidant defense of vascular walls and neural cells, especially under oxidative stress conditions, while GPx-2 serves as the predominant isoform in the lungs, with expression regulated by the transcription factor Nrf2