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The immunomodulatory consequences manifest through dual mechanisms including TME immunosuppression driven by M2 macrophage polarization and immune evasion mediated via glutathione dependent redox homeostasis disruption

VNS acts as a significant link between the endocrine/systemic pathway and the neuronal pathway

There was a significant drug effect (F 3,24 = 42.76

Immunoblot of indicated proteins in whole-cell lysates and mitochondria isolated from HEK-293T (top) and HeLa (bottom) SLC25A39 knockout cells expressing a vector control or SLC25A39 cDNA