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The interaction between interleukin-22 and interleukin-17 inhibits keratinocyte differentiation while increasing their proliferation and motility, leading to nuclear retention within the stratum corneum, epidermal hyperplasia (acanthosis), and elongation of the epidermal rete ridges (papillomatosis) all of which are characterized by psoriatic skin plaques (Becher and Pantelyushin 2012)
Can be taken daily if cost permits, but the same injection-day avoidance principle applies
Duarte AI, Santos P, Oliveira CR, Santos MS, Rego AC (2008) Insulin neuroprotection against oxidative stress is mediated by Akt and GSK-3 signaling pathways and changes in protein expression
Neuroscience 170 , 12391248 (2010)
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