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It describes a commercial and scientific strategy: take an existing biologic molecule, engineer a meaningful clinical improvement, and submit it as a new molecular entity through a full Biologics License Application (BLA), not the abbreviated 351(k) biosimilar pathway

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Interestingly, both estradiol and leptin receptors colocalize in kisspeptinergic neurons, which are considered to be the link between nutrition (metabolism) and reproduction (ovulatory function) (151)