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The patients must also be informed about the potential for developing tolerance and actions if they suspect development of tolerance [see Warnings and Precautions (5.4)] and the risk of dependence and the potential consequences of abuse [see Warnings and Precautions (5.6), Drug Abuse and Dependence (9), and Overdosage (10)]

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The SURMOUNT trial program, which is the largest clinical trial series evaluating tirzepatide for obesity, has produced results that have reshaped how clinicians think about medically supervised weight loss

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