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A previous study of liraglutide on mice fed a diet lacking methionine and choline also found that GLP-1RAs not only could improve IR, but also reduce harmful ceramide/nerve sheath types, and reduce NAFLD inflammation and fibrosis (191)
In addition to our included studies, there were more original studies excluded from our meta-analysis due to methodological differences and a lack of appropriate data, which provide additional support for GLP-1RAs role in reducing alcohol consumption
But "modest effects in animal studies" is an enormous distance from "clinically meaningful weight loss in humans." The gap between preclinical promise and proven human results is where most supplement claims fall apart
These are aimed at giving patients more flexibility, reducing the cost burden and making adoption of these anti-obesity therapies easier
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