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Endocrinology 155 , 21122121 (2014)

[DOI] [PubMed] [Google Scholar] 153.Maciel M.G., Beserra B.T.S., Oliveira F.C.B., Ribeiro C.M., Coelho M.S., Neves F.d.A.R., Amato A.A

The answer is complex, but it is likely in large part due to the combination of its ubiquity in the body and the significant role it plays

12 The de novo synthesis of NAD+ has been shown to enhance mitochondrial function, with enzymes like ACMSD playing a critical role in regulating cellular NAD+ levels and sirtuin activity