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In relation to CaMKK2, a pharmacogenomic study using a methamphetamine-induced model of bipolar disorder in mice found that valproate treatment increased Camkk2 mRNA expression in the brain caudate nucleus [155]

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Future research should further elucidate the regulatory roles of microbial metabolic networks (e.g., bile acids, SCFAs, and tryptophan metabolites) and leverage multi-omics technologies to refine personalized treatment strategies, thereby distinguishing therapeutic responses across PCOS subtypes and advancing precision medicine in reproductive endocrinology

Cell Reports , 44 (3), 115370 Sannino, S., Manuel, A