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This is theoretical and not proven in clinical trials, but the mechanistic pathways are well-documented

At day 14 post-intervention, the mean of the percentage change (SD) of AKR1C1 expression in tumor cells was 62.1 (312.99) and 867.4 (2097.8) for SFN and placebo groups, respectively (30)

Low levels of glutathione are also associated with chronic exposure to chemical toxins and alcohol, cadmium exposure, smoking, AIDS/HIV, macular degeneration, Parkinsons disease, and other neurodegenerative disorders