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Lillys Mounjaro (Tirzepatide), a GIP/GLP-1 Dual Agonist, Demonstrated Cardiovascular Protection in Landmark Head-to-Head Trial, Reinforcing Its Benefit in Patients with Type 2 Diabetes and Heart Disease (Eli Lilly and Company, accessed 19 August 2025)

Despite immunosuppressive therapies 10-20% of patients will progress to end-stage renal disease (ESRD) within 5 years of diagnosis

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Furthermore, GLP-1 has been shown to stimulate calcitonin secretion from the thyroid gland, which may further contribute to protective effects on bone, 25 but whether this action is relevant in humans still needs to be clarified