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I would anticipate that individuals following evidence-based muscle building protocols (high protein, progressive overload, adequate recovery) would see meaningfully better lean mass outcomes than what the trials suggest

In addition to its intrinsic role in catalysing glycolysis, PFKFB3 was recently reported to be involved in NLRP3 inflammasome-mediated inflammation, oxidative stress, and pyroptosis during sepsis [52]

An important origin of ROS within erythrocytes is the autoxidation of hemoglobin, generating superoxide radicals (Cimen, 2008)