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Ann Family Med 10(1):1522 Rubin RR (2005) Adherence to pharmacologic therapy in patients with type 2 diabetes mellitus

The formation of this phenomenon is closely associated with the dysregulation of NF-B, matrix metalloproteinase (MMP), fibronectin (FN), -SMA, and connective tissue growth factor (CTGF), as well as the modulation of the renin-angiotensin-aldosterone system (RAAS) (Oatmen et al., 2020)

Loss of AMP-activated protein kinase-alpha2 impairs the insulin-sensitizing effect of calorie restriction in skeletal muscle

Thus, macrophage ferroptosis and macrophage-derived foam cell ferroptosis persist throughout plaque formation and progression to advanced unstable plaques