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It's also worth noting that many initial studies focused on individuals without pre-existing major depression

The primary outcome of interest was the incidence of dementia, Alzheimers disease, vascular dementia, frontotemporal dementia, Parkinsons disease, extrapyramidal and movement disorders, and dementia with Lewy bodies

RSL3 interacts with enzymes involving nucleophilic interactions, such as cysteine, serine, and selenocysteine, and modifies GPX4, rendering the enzyme inactive [123]