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The An 2019 clinical trial in Annals of Dermatology tested a crosslinked hyaluronic acid microneedle patch loaded with sh-Oligopeptide-1 and Acetyl Hexapeptide-8 against vehicle control in Korean women with peri-orbital wrinkles, and found significant reductions in wrinkle depth and improvements in skin elasticity over 8 weeks [37]

However, the field is not staying still, and recently published data from the high-dose semaglutide STEP Phase 3 trials (44) and the SURPASS Phase 3 trials of the GLP-1/glucose-dependent insulinotropic peptide (GIP) co-agonist tirzepatide (90) have set the efficacy bar high in terms of weight loss and glycaemic improvement

increased permeability with immature mechanisms for clearance of lung liquid