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lactis HN019 in pregnant mice attenuated periodontitis-induced intestinal damage, systemic inflammation, and adverse pregnancy outcomes like fetal growth restriction (Gonzalez et al., 2025), while Clostridium butyricum MIYAIRI 588 alleviates periodontal bone loss in diabetic mice via gut microbiota regulation (Zhang et al., 2023a)

Study Highlights: - Participants received cryoneurolysis to the sciatic, femoral, obturator, and lateral femoral cutaneous nerves