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Synergistic Effect : The combined action on both GLP-1 and GIP receptors is speculated to produce a synergistic effect that could result in greater glycemic control and weight reduction than targeting either receptor alone, based on the positive clinical trial outcomes noted with the first approved dual GLP-1/GIP receptor agonist, tirzepatide

Skin that has been stretched significantly over a longer period, or that has less elasticity due to age or prior weight fluctuations, is more likely to remain loose after significant fat loss

With the recent confirmation of the therapeutic role of GLP-1RA in MASLD, a broader dosage spectrum is needed to respond to individualized treatments with different metabolic profiles

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