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If a lack of vitamin B12 prevents the brain from making these chemicals, you may experience common depressive symptoms, like: Anxiety Irritability Sadness Restlessness Additionally, a B12 deficiency can: Lead to increased amounts of the amino acid homocysteine, which can make depression worse [9]

NAD+ injections carry their own clinic-dependent cost

The trade-off is the extra step at home

For a plain-language summary of growth hormone physiology and its role in body composition, sleep, and tissue repair, a peer-reviewed Nature Reviews Endocrinology paper examining the role of the growth hormone / IGF-1 axis in obesity, adult body composition, and metabolic regulation is a strong starting point