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The results revealed that semaglutide led to significant improvements in heart failure symptoms, exercise ability, and weight loss compared to the placebo

Selective small molecule agonists have been developed to activate many of these receptors, notably G protein-coupled receptor 40 (GPR40 [free fatty acid receptor (FFAR) 1]), GPR119 and GPR120 (FFAR4), and several have shown efficacy in animal models

The most commonly reported adverse effects of semaglutide are gastrointestinal in nature, occurring in approximately 10-40% of patients according to the SmPC