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Not all adolescents respond equally to GLP-1 therapies, suggesting that genetic and metabolic profiling could help determine which patients benefit most from single, dual (GLP-1/GIP or GLP-1/GCGR), or triple agonists

Consequently, this results in a reduction in the expression of PGC-1 (Pirooznia et al., 2020)

Inclusion criteria: Diagnosed with type 2 diabetes and 50 years of age and established CVD or CKD OR 60 years of age with at least 1 CV risk factor a Primary composite outcome Time from randomization to first occurrence of MACE: ASCVD=atherosclerotic cardiovascular disease

It plays several important roles in metabolism