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- Most evidence comes from animal studies - Human data is extremely limited - No FDA approval for orthopedic use - Clinical benefit in musculoskeletal conditions remains unproven While the biology is interesting, potential does not equal proven clinical outcomes

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Further, the authors noted that participants who received epithalamin had lower rates of ischemic heart disease as well as improved levels of key biomarkers such as cortisol and insulin

In EOFAD, there are mutations in the PS1, PS2, and APP genes, which leads to excessive production of -amyloid (Wu et al