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10.1038/nrcardio.2017.65 52 DuringM

Melatonin is metabolized by hepatic cytochrome P450 (CP450) into 6-hydroxymelatonin

Oxidative stress: the role of antioxidant phytochemicals in the prevention and treatment of diseases

Frondoside A downregulates Bcl-2 and survivin, increases ROS production, and promotes cytochrome c release, ultimately triggering mitochondrial apoptosis c release, ultimately triggering mitochondrial apoptosis (127)