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Imbalance in mitochondrial fission and fusion is a key trigger for Parkinsons disease, and defects in mitochondrial dynamics limit mitochondrial movement, leading to a reduction in ATP, excessive oxidative stress, and mtDNA deficiency, which ultimately leads to cell death (Geng et al., 2019)

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2025 Jan 15;15(1):e089477.

Research due to be presented at the American Academy of Neurologys 77th Annual Meeting in early April 2025 and which is yet to undergo peer review has found that moderate-to-vigorous exercise is linked to a lower likelihood of developing a range of neuropsychiatric diseases, including dementia and depression