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In human narcolepsy patients there is a significant reduction in the amount of detectable orexin A and orexin B as well as an 80%100% reduction in the number of neurons that contain detectable prepro-orexin mRNA

Clinical Pharmacology (12.3).] Sitagliptin Of the total number of subjects (N=3884) in clinical studies of sitagliptin, 725 patients were 65 years and over, while 61 patients were 75 years and over

5 Discussion: perspective and open questions While the identification of RAiNs (Sebastian et al., 2012) and VAPB (Janikiewicz et al., 2018), which likely compromise the biophysical environment required for LLPS and biomolecular condensate nucleation in -cells (Huang et al., 2025) or only delay further decay is essential for de-risking clinical translation and defining the therapeutic window for these agents in late-stage pathologies