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It is easy to see why semaglutide was the top-selling drug in the United States in 2023 ($38.6 billion in sales), with tirzepatide coming in eighth ($13.2 billion)

These effects influence hunger and appetite, which, in turn, lead to weight reduction by delaying digestion and promoting satiety

18 Table 4 Time to Improvement of Abnormalities in Vitamin B12 Deficiency After Initiation of Treatment A 2005 Cochrane review involving 108 patients with vitamin B 12 deficiency found that high-dose oral replacement (1 mg to 2 mg per day) was as effective as parenteral administration for correcting anemia and neurologic symptoms

A 2024 study published in Nutrients found that yerba mate consumption increased levels of the hormone GLP-1 in mice, leading to enhanced feelings of fullness and reduced appetite