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A recent publication describes similar results with broad ActRIIA/B receptor blockade during GLP-1 RA-induced weight loss in obese mice, i.e., prevention of muscle loss with increased fat loss, resulting in multiple metabolic benefits 45

Recent post mortem studies revealed that GLP-1R expression was downregulated in the dorsal lateral prefrontal cortex and hippocampus of patients suffering from mood disorders, and those changes further correlated with an elevated body mass index (BMI) [79]

The Emergence of GLP-1 Agonists Building upon the natural roles of GLP-1, researchers developed GLP-1 agonists, which are drugs designed to mimic the effects of the native hormone, consequently fostering a conducive environment for weight loss