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Fifth, we split the GLP-1 RA group into specific drug groupsliraglutide, semaglutide, exenatide, dulaglutide, and lixisenatidebased on the drug of which they had received the largest cumulative dose during the study period

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For example, in head-to-head trials, patients on the highest dose of Zepbound lost up to 22.5% of their body weight over 72 weeks, while those taking semaglutide GLP-1 (Wegovy) lost about 15% over a similar period

The trade-off is that growth hormone stays elevated for longer stretches, which can raise the risk of side effects such as insulin resistance, fluid retention, or joint stiffness