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Mental health issues like depression, panic attacks, anxiety, and PTSD are common in people with opiate addictions

Again and again, regulators said they could find little data on safety or effectiveness and raised concerns about risks of contamination, allergic reactions and quality control

The most well-documented false positive culprits include ibuprofen and certain NSAIDs producing false cannabinoid positives on some older assays, quinolone antibiotics like levofloxacin producing false opioid positives, pseudoephedrine (found in many cold medications) producing false amphetamine positives, ranitidine producing false methamphetamine positives on some immunoassays, sertraline and certain other antidepressants producing false benzodiazepine or amphetamine positives on some platforms, and dextromethorphan producing false PCP positives

However, dedicated immunogenicity data are sparse