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While earlier studies suggested a possible modest increase in risk, more recent comprehensive analyses have found no significant association after adjusting for confounding factors such as obesity, diabetes duration, and concurrent medications

In a genetic preclinical study, embryonic GIPR knockout mice fed a high-fat diet were protected from obesity, supporting the role of GIPR antagonism as a method to promote weight loss and prevent weight gain (67)

A recent study showed a lower risk association of semaglutide with suicidal ideation compared to non-GLP1R agonist anti-obesity and anti-diabetes medications (41)

This does not mean GLP-1 therapy is ineffective