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10.1038/mp.2011.160 104 RonceroC.DaigreC.GonzalvoB.ValeroS.CastellsX.Grau-LpezL.et al (2013)

While this makes them powerful tools in medicine and research, it also introduces questions about safety and regulation when used for personal use

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For example, some MIC B12 (Methionine, Inositol, Choline + B12) blends are more sensitive to temperature and should be refrigerated both before and after first use