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Elevated H 2 O 2 production by SOD activity leads to an early inhibition of EAS enzymes activity such as TrxR (Schallreuter et al., 1991a), CAT and GPx, which in turn, leads to an increase in Fenton reaction, increasing hydroxyl concentrations (Fe 2+ + H 2 O 2 Fe 3+ + OH + OH) to a toxic level, that ultimately, leads to a significant peroxidation in several cellular components (membranes, proteins, mitochondria, and DNA) (Schallreuter, 2014)

Statistical analysis Dichotomous outcomes are quantified by calculating relative risks (RRs) coupled with 95% confidence intervals (CIs)

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