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Weeks 5 to 8 (dose escalation to 0.6 mg) Nausea becomes more noticeable in some individuals as the dose doubles

Impaired spermatogenesis was not obvious, and mature spermatogenic cells were absent in groups C and D

Electrolytes and kidney function also deserve attention, since both drugs can affect them

These digestive effects are directly related to how the medication works to slow gastric emptying and are usually most noticeable when first starting treatment or increasing the dose