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Since oxidative stress and inflammation are closely associated with insulin resistance, it is conceivable that the AGE-RAGE system may play a role in pathogenesis of insulin resistance observed in PCOS [30], regardless of circulating glucose levels, weight and obesity

In clinical trials, tirzepatide significantly reduced HbA1c levels (by up to 2.24%) and promoted substantial weight loss (by up to 11.2 kg) ( Molecular Mechanisms: Tirzepatide may positively impact cardiovascular health through multiple mechanisms (see Figure 3)

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