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Also known as hypersensitivity to the heat, heat intolerance is more than just feeling uncomfortable when temperatures rise

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-Poly(glutamic acid) from marine Bacillus not only blocks early viral replication but also upregulates proinflammatory cytokines such as TNF- and IL-1, further contributing to viral elimination [133], marine compounds can modulate signaling pathways including NF-B, which regulates expression of antiviral cytokines, providing an indirect yet potent mechanism to inhibit HSV infection