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Cortical spreading depression (CSD), characterized by a strong wave of neuronal depolarization accompanied by glial and vascular activation, is widely believed to underlie the aura phase of migraines (24)

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It is also thought that T4 may increase cell migration, which could increase metastasis.[ref] For example, thyroid cancers often have higher TMSB4X expression.[ref] Peptide fragment: Ac-SDKP Thymosin beta 4 can be broken down into a shorter peptide called Ac-SDKP, which is an active peptide that reduces inflammation and fibrosis

Third, in cardiac ischemia models in rodents, Tbeta4 demonstrated cardioprotective effects linked to activation of integrin-linked kinase (ILK)