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In a substudy of the LEAN trial that included 14 patients, liraglutide significantly reduced low-density lipoprotein (LDL)-cholesterol, ALT, serum leptin, adiponectin, and CCL-2 concentrations (all p 10%), the 24-week effect of treatment with 10 g exenatide and insulin glargine twice daily was compared [48]

In addition to effective and sustained weight loss, many patients experience improved health markers, including lower blood sugar levels, better blood pressure, and healthier cholesterol numbers

Underlying conditions affecting fertility : If you have PCOS, irregular periods, or other reproductive health concerns, your healthcare provider can assess whether weight loss through GLP-1 treatment might benefit your fertility and discuss alternative or complementary approaches

Clinical trials show that drugs like semaglutide can help people lose 15% or more of their body weight, while even the most intensive lifestyle interventions typically achieve 510% weight loss