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Peak neurotransmitter effects occur within 2 to 6 hours of injection, so a morning dose aligns dopaminergic activity with natural wakefulness

The therapeutic window appears well-established at these dosing levels, with higher doses unlikely to provide proportional additional benefits while potentially increasing adverse events

The results support the development of Sanionas proprietary formulation called Tesomet, which combines tesofensine with another compound and is currently in Phase 2 trials for rare eating disorders

Conclusions Overall, our study supported that metformin attenuates IIR-induced intestinal ferroptosis through modulation of the gut microbiota