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Collectively, these genetic lesions converge on a common pathway: failure to establish or maintain immune tolerance to pancreatic beta cells

When thinking of gout, a useful model has been proposed by Wortmann.1 Uric acid crystals can be thought of like matches, which can sit quietly or can be ignited

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The active fragments signal skin repair through receptors that the body recognises as familiar, which is part of why the irritation profile is so much lower