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R., Warner, A

Combine tirzepatide with strength training, adequate protein, and gradual calorie reduction to encourage fat loss while protecting muscle

Patients with a history of medullary thyroid carcinoma or multiple endocrine neoplasia type 2 should avoid all GLP-1 agonists, including orforglipron

Persistent unexplained elevation alongside an abnormal CBC or differential, constitutional symptoms such as unexplained weight loss, night sweats, or persistent fever, or organ-specific findings all raise the need for referral