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For those experiencing severe symptoms, reducing all exercise to gentle walking may be essential in the short-term

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Additionally, GSTO1-1 has been shown to modulate Akt and MEK1/2 kinase pathways in human neuroblastoma SH-SY5Y cells, where the catalytic activities of the isoenzyme was shown to suppress the activation of these two kinases (either directly or in a complex) to maintain basal levels [69]

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