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For the overwhelming majority of individuals pursuing meaningful, sustained weight reduction, semaglutide (or the more potent tirzepatide if greater weight loss is the goal) is the evidence-backed choice

Cells 3:363385 Ji Y, Chen S, Li K, Xiao X, Xu T, Zheng S (2014) Upregulated autocrine vascular endothelial growth factor (VEGF)/VEGF receptor-2 loop prevents apoptosis in haemangioma-derived endothelial cells