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These actions comprise feeling helpless and anhedonia, two hallmarks of depression symptoms (140, 141)
At the same time, broad activity can make mechanism assignment more difficult because different tissues may produce similar outcomes through different intermediate pathways
Furthermore, studies using diet-induced models of MASLD have shown that e-cigarette exposure exacerbates preexisting liver injury, worsening steatohepatitis through amplified oxidative stress, mitochondrial dysfunction, and inflammatory responses [134]
This condition is mainly characterized by increased visceral adiposity, abnormal lipid profiles, decreased quality of life, and other important risk factors
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