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During the same timeframe the share of Ozempic users who were overweight but did not have diabetes increased by 225%.2 The public perception of Ozempic as a magic weight loss cure is responsible for this increase, and is both untenably expensive, and medically inaccurate

New @NEJM review on GLP-1 receptor agonists just out: effects on glucose, weight, cardiovascular outcomes, #MASLD and kidney outcomes but important questions remain about durability, lean mass (muscle + bone) loss, and long-term safety

The half-lives of compounds 1 , 2 , 5 , 9 , 11 , 14 , 16 , 22 and 23 in presence of NEP 24.11 and in presence of mouse plasma were determined by following the decay of the analogues by LCMS (Table 2)