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More encouraging research in mice indicates that MK677 administration over a lifetime can reduce amyloid beta buildup and that this does, in fact, decrease neuron and synapse loss

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Key evidence comes from STEP (semaglutide for weight management, The New England Journal of Medicine , 2021), SURMOUNT (tirzepatide for weight management, NEJM 2022), and SURMOUNT-OSA (tirzepatide for obstructive sleep apnea, NEJM 2024)